Stewart Karen E, Haller Deborah L, Sargeant Carol, Levenson James L, Puri Puneet, Sanyal Arun J
Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Liver Int. 2015 Mar;35(3):936-43. doi: 10.1111/liv.12483. Epub 2014 Mar 10.
BACKGROUND & AIMS: Weight management is a cornerstone of treatment for overweight/obese persons with non-alcoholic fatty liver disease (NAFLD). This exploratory study sought to: (i) evaluate readiness to change weight-related behaviours; (ii) assess psychosocial characteristics that may interfere with weight loss; and (iii) evaluate how baseline psychosocial features associate with 6-month change in weight in persons with NAFLD receiving standard medical care. The purpose of this investigation was to develop hypotheses regarding relationships between psychosocial factors and weight for use in future fully powered studies and clinical interventions
Fifty-eight overweight/obese participants with NAFLD completed baseline measures of personality, psychiatric symptoms and readiness for behaviour change and were followed up for 6 months in standard care.
One-third of participants (31.0%) were not interested in making weight-related behaviour changes; 58.6% were considering making a change, and 10.4% of individuals were actively working on or preparing to change. Six-month change in weight was non-significant and was not associated with baseline readiness for change. Depression, low conscientiousness and high neuroticism were associated with higher weight at 6-month follow-up with small to large effect sizes.
Although participants received nutritional education and guidance, very few individuals presented in the active stage of change. Although readiness for change did not predict subsequent change in weight, personality factors and psychiatric symptoms were associated with weight outcomes. Integrated multidisciplinary approaches that address psychiatric needs and provide behavioural support for weight loss may help patients with NAFLD implement sustained lifestyle changes.
体重管理是超重/肥胖的非酒精性脂肪性肝病(NAFLD)患者治疗的基石。这项探索性研究旨在:(i)评估改变与体重相关行为的意愿;(ii)评估可能干扰体重减轻的心理社会特征;(iii)评估在接受标准医疗护理的NAFLD患者中,基线心理社会特征与6个月体重变化之间的关联。本调查的目的是就心理社会因素与体重之间的关系提出假设,以供未来进行充分有力的研究和临床干预时使用。
58名超重/肥胖的NAFLD参与者完成了人格、精神症状和行为改变意愿的基线测量,并在标准护理下随访6个月。
三分之一的参与者(31.0%)对改变与体重相关的行为不感兴趣;58.6%的人在考虑做出改变,10.4%的人正在积极努力或准备改变。6个月时体重变化不显著,且与基线改变意愿无关。抑郁、低尽责性和高神经质与6个月随访时较高的体重相关,效应大小从小到中。
尽管参与者接受了营养教育和指导,但很少有人处于积极改变阶段。尽管改变意愿并不能预测随后的体重变化,但人格因素和精神症状与体重结果相关。综合多学科方法,解决精神需求并为体重减轻提供行为支持,可能有助于NAFLD患者实现持续的生活方式改变。