Mirzaii-Dizgah Iraj, Riahi Esmail
Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Indian J Med Res. 2013 Dec;138(6):861-5.
BACKGROUND & OBJECTIVES: Accurate and rapid diagnosis of acute myocardial infarction (MI) is of major clinical significance. The troponin is the biomarker of choice for detection of cardiac injury. The objective of this study was to identify salivary levels of cardiac troponin I (cTnI) in patients with acute MI.
Thirty patients with acute MI and 28 normal healthy individuals were included in the study. cTnI levels were assayed in serum and saliva 12 and 24 h of acute MI by ELISA method.
In patients with acute MI, the serum and resting (unstimulated) saliva concentrations of cTnI, but not stimulated saliva cTnI, at both 12 and 24 h of onset of MI, were significantly higher than in controls. Resting saliva cTnI concentrations correlated significantly with serum cTnI levels (spearman rho = 0.34 and 0.45 in the total individuals and in the MI patients respectively).
INTERPRETATION & CONCLUSIONS: The present results suggest that saliva can be an analytical matrix for measurement of cTnI in patients with acute MI. Further studies may reveal capability of salivary cTnI for being used for developing point-of-care testing for early detection of MI in pre-clinical settings.
急性心肌梗死（MI）的准确快速诊断具有重要临床意义。肌钙蛋白是检测心脏损伤的首选生物标志物。本研究的目的是确定急性心肌梗死患者唾液中心肌肌钙蛋白I（cTnI）的水平。
本研究纳入了30例急性心肌梗死患者和28名正常健康个体。采用酶联免疫吸附测定法（ELISA）在急性心肌梗死发病12小时和24小时时检测血清和唾液中的cTnI水平。
在急性心肌梗死患者中，心肌梗死发病12小时和24小时时，血清和静息（未刺激）唾液中的cTnI浓度显著高于对照组，但刺激唾液中的cTnI浓度无明显差异。静息唾液cTnI浓度与血清cTnI水平显著相关（在所有个体和心肌梗死患者中，斯皮尔曼相关系数分别为0.34和0.45）。
目前的结果表明，唾液可作为急性心肌梗死患者cTnI检测的分析基质。进一步的研究可能揭示唾液cTnI在临床前环境中用于开发即时检测以早期检测心肌梗死的能力。
