感知杂交体--TLR9 的新型 PAMP。
Sensing the hybrid--a novel PAMP for TLR9.
机构信息
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
出版信息
EMBO J. 2014 Mar 18;33(6):529-30. doi: 10.1002/embj.201487747. Epub 2014 Feb 12.
Abstract
The host immune response is initiated by pattern recognition receptors (PRR) when triggered by specific ligands known as pathogen-associated molecular patterns (PAMP). Toll-like receptor 9 is highly expressed in plasmacytoid dendritic cells and is well described as a PRR for CpG DNA which induce the production of cytokines and type I interferons. In this issue of The EMBO Journal, Rigby et al identify RNA-DNA hybrids as a novel PAMP specifically recognized by TLR9 in dendritic cells.
摘要
当特定配体（称为病原体相关分子模式，PAMP）触发时，模式识别受体（PRR）会启动宿主免疫反应。Toll 样受体 9 在浆细胞样树突状细胞中高度表达，并且被很好地描述为 CpG DNA 的 PRR，CpG DNA 诱导细胞因子和 I 型干扰素的产生。在本期《欧洲分子生物学学会杂志》中，Rigby 等人确定 RNA-DNA 杂交体为树突状细胞中 TLR9 特异性识别的新型 PAMP。
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2
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J Infect Dis. 2014 May 15;209(10):1623-7. doi: 10.1093/infdis/jit807. Epub 2013 Dec 10.
3
Immune sensing of DNA.DNA 的免疫感应。
Immunity. 2013 May 23;38(5):870-80. doi: 10.1016/j.immuni.2013.05.004.
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The control of adaptive immune responses by the innate immune system.先天免疫系统对适应性免疫反应的控制。
Adv Immunol. 2011;109:87-124. doi: 10.1016/B978-0-12-387664-5.00003-0.
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