Belavý D L, Möhlig M, Pfeiffer A F H, Felsenberg D, Armbrecht G
Center of Muscle and Bone Research, Charité Universitätsmedizin Berlin, Berlin, Germany.
Clinic for Endocrinology, Diabetes and Nutrition, Charité Universitätsmedizin Berlin, Berlin, Germany.
Int J Obes (Lond). 2014 Nov;38(11):1478-80. doi: 10.1038/ijo.2014.26. Epub 2014 Feb 13.
We hypothesised that strict inactivity (bed rest) would lead to regional differences in fat deposition. Twenty-four male subjects underwent 60 d bed rest and remained inactive (n = 9), performed resistance exercise plus whole-body vibration (RVE; n = 7) or resistance exercise only (RE; n = 8). Fat mass was assessed via dual X-ray absorptiometry. In the inactive subjects, fat deposition differed between body regions (P = 0.0005) with android region visceral adipose tissue increasing the most (+29% at the end of bed rest), followed by remainder of the trunk (from chin to the iliac crest; +10%) and the arms and legs (both +7%). Insulin sensitivity reduced in the inactive subjects at the end of bed rest (P = 0.036). RE did not have a significant impact on regional fat mass changes (P ⩾ 0.055). In RVE, increases in visceral adipose tissue (-14%; P = 0.028 vs inactive subjects) and in the arms (arms -8%, P = 0.011 vs inactive) were not seen. We conclude that inactivity leads to a preferential increase in visceral adipose tissue.
我们假设严格限制活动（卧床休息）会导致脂肪沉积出现区域差异。24名男性受试者接受了60天的卧床休息，其中保持不活动状态的有9人，进行抗阻运动加全身振动的有7人（RVE组），仅进行抗阻运动的有8人（RE组）。通过双能X线吸收法评估脂肪量。在不活动的受试者中，身体各部位的脂肪沉积存在差异（P = 0.0005），腹部区域的内脏脂肪组织增加最多（卧床休息结束时增加29%），其次是躯干其余部位（从下巴到髂嵴；增加10%）以及手臂和腿部（均增加7%）。卧床休息结束时，不活动的受试者胰岛素敏感性降低（P = 0.036）。RE对区域脂肪量变化没有显著影响（P⩾0.055）。在RVE组中，未观察到内脏脂肪组织增加（-14%；与不活动受试者相比，P = 0.028）以及手臂脂肪增加（手臂减少了8%，与不活动受试者相比，P = 0.011）。我们得出结论，不活动会导致内脏脂肪组织优先增加。
