Weidhase L, Hentschel H, Mende L, Schulze G, Petros S
Department für Innere Medizin, Neurologie und Dermatologie, Interdisziplinäre Internistische Intensivmedizin, Universitätsklinikum Leipzig AöR, Liebigstr. 20, 04103, Leipzig, Deutschland,
Internist (Berl). 2014 Mar;55(3):281-94; quiz 295-6. doi: 10.1007/s00108-013-3401-x.
Acute poisoning is one of the more frequent presentations in acute and emergency medicine. Poisoning with pharmaceuticals is predominantly observed in adults. A detailed medical history and an accurate clinical examination establish the basis for the diagnostics. Typical poisoning syndromes can be classified based on the clinical presentation. Drug screening in urine and examination of blood alcohol levels are useful additional tools because of the rapid and widespread availability. Securing vital organ functions is the mainstay of treatment and early contact with a poisons centre is useful for the assessment of the hazard and the further procedures. Primary and secondary poison elimination methods should be carefully considered because of insufficient evidence. Specific antidotes are only available for a few poisoning cases.
急性中毒是急重症医学中较为常见的病症之一。药物中毒主要见于成年人。详细的病史和准确的临床检查是诊断的基础。典型的中毒综合征可根据临床表现进行分类。由于尿液药物筛查和血液酒精水平检测快速且普遍可用,因此它们是有用的辅助检查手段。保障重要器官功能是治疗的关键,尽早联系中毒控制中心有助于评估风险及后续处理。鉴于证据不足,应谨慎考虑一级和二级毒物清除方法。仅有少数中毒病例有特效解毒剂。