Zhang Q Z, Tian Y, Lao Y Z, Li Z-G
School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, 518055, P. R. China.
Curr Med Chem. 2014;21(21):2438-52. doi: 10.2174/0929867321666140205130835.
α-Helixes are important structural motifs of protein three dimension structures and are largely involved in protein- protein interactions. This review covers the recent advances of the peptide stabilizing methodologies and introduces their applications in cancer research.
α-螺旋是蛋白质三维结构的重要结构基序,在很大程度上参与蛋白质-蛋白质相互作用。本综述涵盖了肽稳定化方法的最新进展,并介绍了它们在癌症研究中的应用。