Department of Biochemistry & Molecular Biology, Monash University Clayton, VIC, 3800, Melbourne, Victoria. Australia.
Biomedicine Discovery Institute & Department of Biochemistry and Molecular Biology, Monash University, Wellington Rd, Clayton, Vic. 3800. Australia.
Curr Pharm Des. 2017;23(26):3772-3785. doi: 10.2174/1381612823666170616083031.
β-Amino acids are being increasingly used in the design of bioactive ligands and more recently in the generation of novel biomaterials. Peptides containing either individual β-amino acid substitutions or peptides comprised entirely of β-amino acids, display unique properties in terms of their structural and/or chemical characteristics. β-Peptides form well-defined secondary structures that exhibit different geometries compared to the corresponding α-peptides. β-Peptides, including α-peptides containing only one or two β-amino acids, can be easily modified with different functional groups and are metabolically stable and, together with the predictable side chain topography, have led to the design of a growing number of bioactive β-peptides with a range of biological targets and therapeutic applications. More recently, our understanding of the folding and self-assembly of β-peptides has resulted in the generation of novel biomaterials. The focus of this review is to examine how the structural and chemical properties of β-peptides have been exploited in the design of bioactive peptides and selfassembled nanomaterials.
β-氨基酸在生物活性配体的设计中被越来越多地使用，最近在新型生物材料的生成中也得到了应用。含有单个β-氨基酸取代的肽或完全由β-氨基酸组成的肽，在其结构和/或化学特性方面表现出独特的性质。β-肽形成了具有良好定义的二级结构，与相应的α-肽相比具有不同的几何形状。β-肽，包括仅含有一个或两个β-氨基酸的α-肽，可以很容易地用不同的官能团进行修饰，并且代谢稳定，加上可预测的侧链拓扑结构，导致了越来越多具有各种生物学靶标和治疗应用的生物活性β-肽的设计。最近，我们对β-肽的折叠和自组装的理解导致了新型生物材料的产生。本文的重点是研究如何利用β-肽的结构和化学性质来设计生物活性肽和自组装纳米材料。
