Milne S D, Connolly P
Department of Biomedical Engineering, University of Strathclyde, Scotland, UK.
J Wound Care. 2014 Feb;23(2):53-4, 56-7. doi: 10.12968/jowc.2014.23.2.53.
This study examines the effect of various wound dressings on the pH levels of a wound, using a simulated wound environment.
The pH levels of a 4 different wound dressings (manuka honey dressing, sodium carboxymethylcellulose hydrofiber dressing, polyhydrated ionogen-coated polymer mesh dressing, and a protease modulating collagen cellulose dressing) were tested in a simulated horse serum wound environment. The effect of local buffering was observed and pH changes in real time were measured.
All dressings were found to have low pH (below pH 4), with the lowest being the protease modulating collage cellulose dressing, with a pH of 2.3. The dressing with the strongest acid concentration was the polyhydrated, ionogen-coated, polymer mesh dressing.
The low pH and strong acidic nature of the dressing investigated indicate that they may play a role in influencing the healing process in a wound.
The authors have no conflicts of interest to declare. This study was funded by the EPSRC.
本研究使用模拟伤口环境，考察各种伤口敷料对伤口pH值水平的影响。
在模拟马血清伤口环境中测试4种不同伤口敷料（麦卢卡蜂蜜敷料、羧甲基纤维素钠水凝胶敷料、多水合离子源涂层聚合物网片敷料和蛋白酶调节胶原蛋白纤维素敷料）的pH值水平。观察局部缓冲作用，并实时测量pH值变化。
发现所有敷料的pH值均较低（低于pH 4），其中最低的是蛋白酶调节胶原蛋白纤维素敷料，pH值为2.3。酸浓度最高的敷料是多水合离子源涂层聚合物网片敷料。
所研究敷料的低pH值和强酸性表明，它们可能在影响伤口愈合过程中发挥作用。
作者声明无利益冲突。本研究由英国工程和自然科学研究委员会资助。
