Faculty of Mechanical Engineering, Laboratory for Characterization and Processing of Polymers, University of Maribor, Smetanova 17, 2000, Maribor, Slovenia.
Faculty of Medicine, Department of Pharmacology, University of Maribor, 2000, Maribor, Slovenia.
AAPS PharmSciTech. 2019 Jan 2;20(1):29. doi: 10.1208/s12249-018-1236-4.
Development of drug-loaded wound dressings is often performed without systematic consideration of the changing wound environment that can influence such materials' performance. Among the crucial changes are the wound pH and temperature, which have an immense effect on the drug release. Detailed release studies based on the consideration of these changing properties provide an important aspect of the in vitro performance testing of novel wound dressing materials. A sodium carboxymethyl cellulose-based wound dressing, with the incorporated non-steroidal anti-inflammatory drug diclofenac, was developed and characterised in regard to its physico-chemical, structural and morphological properties. Further, the influence of pH and temperature were studied on the drug release. Finally, the biocompatibility of the wound dressing towards human skin cells was tested. Incorporation of diclofenac did not alter important properties (water retention value, air permeability) of the host material. Changes in the pH and temperature were shown to influence the release performance and have to be accounted for in the evaluation of such dressings. Furthermore, the knowledge about the potential changes of these parameters in the wound bed could be used potentially to predict, and potentially even to control the drug release from the developed wound dressing. The prepared wound dressing was also proven biocompatible towards human skin cells, making it interesting for potential future use in the clinics.
载药伤口敷料的开发通常没有系统地考虑不断变化的伤口环境，而这些环境会影响这些材料的性能。其中关键的变化包括伤口 pH 值和温度，它们对药物释放有巨大影响。基于这些变化特性的详细释放研究为新型伤口敷料材料的体外性能测试提供了一个重要方面。本文以羧甲基纤维素钠为基质，制备了载非甾体类抗炎药双氯芬酸钠的伤口敷料，并对其理化性质、结构和形态进行了研究。此外，还研究了 pH 值和温度对药物释放的影响。最后，测试了伤口敷料对人体皮肤细胞的生物相容性。双氯芬酸钠的掺入并没有改变基质材料的重要性质（保水值、空气通透性）。pH 值和温度的变化被证明会影响释放性能，在评估这些敷料时必须考虑到这些因素。此外，对这些参数在伤口床中潜在变化的了解可以潜在地用于预测，甚至潜在地控制开发的伤口敷料的药物释放。所制备的伤口敷料对人体皮肤细胞也表现出良好的生物相容性，使其有可能在未来的临床应用中得到应用。
