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静脉麻醉药对缺血再灌注损伤的影响。

The effect of intravenous anesthetics on ischemia-reperfusion injury.

作者信息

Eroglu Ahmet

机构信息

Karadeniz Technical University, Anesthesiology and Intensive Care Medicine, 61000 Trabzon, Turkey.

出版信息

Biomed Res Int. 2014;2014:821513. doi: 10.1155/2014/821513. Epub 2014 Jan 16.

DOI:10.1155/2014/821513
PMID:24527458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3914339/
Abstract

The effects of intravenous anesthetics on ischemia-reperfusion injury (IRI) have been investigated in both animals and clinical studies. The protective effects and the dosages of the intravenous anesthetics on IRI were discussed in this paper. The prevention of the tissue injury after the IRI was demonstrated with intravenous anesthetics in some studies. In the future, the studies should be focused on the dosage of the anesthetics related to diminishing the tissue injuries. Further studies might be required in order to investigate the effects of the anesthetics on molecular levels.

摘要

静脉麻醉药对缺血再灌注损伤（IRI）的影响已在动物和临床研究中得到探究。本文讨论了静脉麻醉药对IRI的保护作用及剂量。一些研究表明静脉麻醉药可预防IRI后的组织损伤。未来，研究应聚焦于与减轻组织损伤相关的麻醉药剂量。可能需要进一步研究以探究麻醉药在分子水平上的作用。

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本文引用的文献

1
Remifentanil ameliorates intestinal ischemia-reperfusion injury.瑞芬太尼可改善肠缺血再灌注损伤。
BMC Gastroenterol. 2013 Apr 22;13:69. doi: 10.1186/1471-230X-13-69.
2
Dexmedetomidine did not reduce the effects of tourniquet-induced ischemia-reperfusion injury during general anesthesia.右美托咪定不能减少全身麻醉期间止血带引起的缺血再灌注损伤。
Kaohsiung J Med Sci. 2013 Feb;29(2):75-81. doi: 10.1016/j.kjms.2012.08.013. Epub 2012 Oct 13.
3
The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats.右美托咪定对大鼠肝缺血再灌注损伤肝及远隔器官的保护作用。
Int J Surg. 2013;11(1):96-100. doi: 10.1016/j.ijsu.2012.12.003. Epub 2012 Dec 20.
4
Pretreatment with intrathecal or intravenous morphine attenuates hepatic ischaemia-reperfusion injury in normal and cirrhotic rat liver.鞘内或静脉内给予吗啡预处理可减轻正常和肝硬化大鼠肝脏缺血再灌注损伤。
Br J Anaesth. 2012 Oct;109(4):529-39. doi: 10.1093/bja/aes209. Epub 2012 Jun 28.
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Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model.异丙酚、硫喷妥钠、依托咪酯和咪达唑仑在胎鼠脑缺血再灌注模型中的神经保护作用
Childs Nerv Syst. 2012 Jul;28(7):1055-62. doi: 10.1007/s00381-012-1782-0. Epub 2012 May 5.
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Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats.瑞芬太尼对大鼠短暂性局灶性脑缺血的神经保护作用。
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Biomarkers of oxidative stress and endothelial dysfunction after tourniquet release in children.止血带释放后儿童氧化应激和内皮功能障碍的生物标志物。
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