Huang Zhan, Bai Yiping, Chen Ying, Chen Ye, Jiang Yuan, Zhou Jun
Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China.
Front Pharmacol. 2024 Feb 20;15:1367170. doi: 10.3389/fphar.2024.1367170. eCollection 2024.
Intestinal ischemia-reperfusion injury (IRI) is a potentially severe clinical syndrome after major surgical procedures. In addition to causing intestinal mucosa injury, intestinal IRI further damages distant organs, causing the severity of the condition in patients. So far, effective therapy for intestinal IRI is still absent, and the survival rate of the patients is low. Previous experimental studies have shown that some anesthetics can alleviate intestinal IRI and protect organs while exerting their pharmacological effects, indicating that reasonable perioperative anesthesia management may provide potential benefits for patients to avoid intestinal IRI. These meaningful findings drive scholars to investigate the mechanism of anesthetics in treating intestinal IRI in-depth to discuss the possible new clinical uses. In the present mini-review, we will introduce the protective effects of different anesthetics in intestinal IRI to help us enrich our knowledge in this area.
肠缺血再灌注损伤(IRI)是 major surgical procedures 后一种潜在的严重临床综合征。除了导致肠黏膜损伤外,肠 IRI 还会进一步损害远处器官,加重患者病情的严重程度。到目前为止,仍缺乏针对肠 IRI 的有效治疗方法,患者的生存率较低。先前的实验研究表明,一些麻醉剂在发挥其药理作用的同时,可以减轻肠 IRI 并保护器官,这表明合理的围手术期麻醉管理可能为患者避免肠 IRI 提供潜在益处。这些有意义的发现促使学者们深入研究麻醉剂治疗肠 IRI 的机制,以探讨可能的新临床用途。在本综述中,我们将介绍不同麻醉剂对肠 IRI 的保护作用,以帮助我们丰富该领域的知识。 (注:原文中“major surgical procedures”表述不太准确,可理解为“重大外科手术” )