鼠伤寒沙门氏菌中提取的孔蛋白肾脏作用的清除率研究。
Clearance studies on the renal action of porins extracted from Salmonella typhimurium.
作者信息
Tufano M A, Capasso G, Anastasio P, Giordano D R, Giordano D, Galdiero E, Sommese L, De Santo N G
机构信息
Chair of Pediatric Nephrology, University of Naples, Italy.
出版信息
Int J Pediatr Nephrol. 1987 Oct-Dec;8(4):193-8.
The effects of porins on renal hemodynamics and on the renal handling of salt and water were studied in rats. The animals injected with 100 micrograms/kg of porins showed an important change in renal potassium handling. In fact the total potassium excretion decreased significantly (p less than 0.02) from 1.11 +/- 0.13 to 0.495 +/- 0.069 muEq/min/100 g and was significantly associated to a reduction of fractional potassium excretion from 21.6 +/- 4.1% to 12.53 +/- 0.95% (p less than 0.001). It is speculated that porins have the capability to close the potassium channels.
在大鼠中研究了孔蛋白对肾血流动力学以及肾脏对盐和水的处理的影响。注射100微克/千克孔蛋白的动物在肾脏钾处理方面出现了重要变化。实际上，总钾排泄量从1.11±0.13显著降低（p<0.02）至0.495±0.069微当量/分钟/100克，并且与钾排泄分数从21.6±4.1%降至12.53±0.95%显著相关（p<0.001）。据推测，孔蛋白具有关闭钾通道的能力。
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