Matera C, Falzarano C, Berrino L, Rossi F
Institute of Pharmacology and Toxicology, University of Naples Federico II, Italy.
J Med. 1992;23(5):327-38.
Endotoxins may interfere with platelet aggregation by interacting with the platelet membrane. The aim of this study was to evaluate the effects of tetanus toxin, Salmonella typhimurium porin, and bacterial lipopolysaccharide (LPS) on platelet aggregation induced by ADP and thrombin in vitro. Spontaneous platelet aggregation and platelet aggregation induced by ADP and thrombin were measured. Our results show that Salmonella typhimurium porin and bacterial LPS enhanced human and rabbit platelet aggregation induced by ADP and thrombin. Tetanus toxin did not affect platelet aggregation.
内毒素可能通过与血小板膜相互作用来干扰血小板聚集。本研究的目的是评估破伤风毒素、鼠伤寒沙门氏菌孔蛋白和细菌脂多糖（LPS）对体外ADP和凝血酶诱导的血小板聚集的影响。测量了自发性血小板聚集以及ADP和凝血酶诱导的血小板聚集。我们的结果表明，鼠伤寒沙门氏菌孔蛋白和细菌LPS增强了ADP和凝血酶诱导的人和兔血小板聚集。破伤风毒素不影响血小板聚集。
