鼠伤寒沙门氏菌孔蛋白对心血管和肾脏器官的影响。
Effect of Salmonella typhimurium porins on the cardiovascular and renal apparatus.
作者信息
Galdiero F, Tufano M A, Rossi F, Filippelli W, De Santis D, Matera C, Berrino L, Marmo E
出版信息
J Med. 1986;17(5-6):285-97.
The cardiovascular effects of porins were evaluated using porins isolated from Salmonella typhimurium SH5014. In dogs porins depress arterial systemic pressure, vasomotor reactivity of norepinephrine and peripheral vagal stimulation. They are capable of modifying the sinocarotidal baroreceptor reactivity. In mice porins increase the cardiotoxic effects of isoprenaline, thyroxine, emetine and of p-nitrophenol. In rats porins increase the arrhythmogenic and lethal effects of BaCl2 and also give rise to renal lesions, probably at the tubular level.
使用从鼠伤寒沙门氏菌SH5014分离出的孔蛋白评估孔蛋白的心血管效应。在犬类中，孔蛋白可降低动脉系统血压、去甲肾上腺素的血管运动反应性以及外周迷走神经刺激。它们能够改变窦颈动脉压力感受器的反应性。在小鼠中，孔蛋白会增强异丙肾上腺素、甲状腺素、吐根碱和对硝基苯酚的心脏毒性作用。在大鼠中，孔蛋白会增强氯化钡的致心律失常和致死作用，还可能导致肾脏病变，可能发生在肾小管水平。
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