State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Carbohydr Polym. 2014 Mar 15;103:520-7. doi: 10.1016/j.carbpol.2013.12.080. Epub 2014 Jan 6.
A newly identified polysaccharide (PSG-1) has been purified from Ganoderma atrum. The study was to investigate the protective effect of PSG-1 on diabetes-induced endothelial dysfunction in rat aorta. Rats were fed a high fat diet for 8 weeks and then injected with a low dose of streptozotocin to induce type 2 diabetes. The diabetic rats were orally treated with PSG-1 for 4 weeks. It was found that administration of PSG-1 significantly reduced levels of fasting blood glucose, improved endothelium-dependent aortic relaxation, increased levels of phosphoinositide 3-kinase (PI3K), phospho-Akt (p-Akt), endothelial nitric oxide synthase (eNOS) and nitric oxide in the aorta from diabetic rats, compared to un-treated diabetics. These results suggested that the protective effects of PSG-1 against endothelial dysfunction may be related to activation of the PI3K/Akt/eNOS pathway.
从灵芝中分离得到一种新的多糖（PSG-1）。本研究旨在探讨 PSG-1 对糖尿病大鼠主动脉内皮功能障碍的保护作用。大鼠给予高脂饮食 8 周，然后注射小剂量链脲佐菌素诱导 2 型糖尿病。糖尿病大鼠给予 PSG-1 口服治疗 4 周。结果发现，与未治疗的糖尿病大鼠相比，PSG-1 给药可显著降低空腹血糖水平，改善主动脉内皮依赖性松弛，增加糖尿病大鼠主动脉中磷酸肌醇 3-激酶（PI3K）、磷酸化 Akt（p-Akt）、内皮型一氧化氮合酶（eNOS）和一氧化氮的水平。这些结果表明，PSG-1 对内皮功能障碍的保护作用可能与激活 PI3K/Akt/eNOS 通路有关。
