State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Int J Biol Macromol. 2013 Jun;57:142-50. doi: 10.1016/j.ijbiomac.2013.03.009. Epub 2013 Mar 13.
A polysaccharide from Ganoderma atrum (PSG-1) was purified and characterized, and its hypoglycemic and hypolipidemic effects were investigated in high fat diet- and streptozotocin-induced type 2 diabetic rats. Oral administration of PSG-1 at 200 or 400 mg/kg body weight significantly reduced fasting blood glucose and serum insulin levels. PSG-1 significantly decreased the levels of serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, free fatty acid and insulin resistance, and increased high-density lipoprotein cholesterol level and insulin sensitivity. In addition, PSG-1 inhibited the expression of pro-apoptotic protein, Bax and increased the expression of anti-apoptotic protein, Bcl-2 in pancreatic cells, suggesting that PSG-1 exerted a protective role in the pancreas of diabetic rats. These results indicated that PSG-1 may have a potential for the treatment of hyperglycemia, hyperlipidemia, hyperinsulinemia and insulin resistance in type 2 diabetes.
从灵芝（PSG-1）中纯化和表征了一种多糖，并在高脂肪饮食和链脲佐菌素诱导的 2 型糖尿病大鼠中研究了其降血糖和降血脂作用。PSG-1 以 200 或 400mg/kg 体重的剂量口服给药可显著降低空腹血糖和血清胰岛素水平。PSG-1 可显著降低血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、游离脂肪酸和胰岛素抵抗水平，同时增加高密度脂蛋白胆固醇水平和胰岛素敏感性。此外，PSG-1 抑制了胰腺细胞中促凋亡蛋白 Bax 的表达，并增加了抗凋亡蛋白 Bcl-2 的表达，表明 PSG-1 对糖尿病大鼠的胰腺具有保护作用。这些结果表明，PSG-1 可能具有治疗 2 型糖尿病高血糖、高血脂、高胰岛素血症和胰岛素抵抗的潜力。
