吸入性麻醉剂对发育中大脑的不良影响。
Adverse effect of inhalational anesthetics on the developing brain.
作者信息
Wang Mike, Zhang John H, Applegate Richard L
机构信息
Department of Anesthesiology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
出版信息
Med Gas Res. 2014 Feb 14;4(1):2. doi: 10.1186/2045-9912-4-2.
Abstract
We did a PubMed search and summarized studies on the potential adverse effect of anesthetics especially neurotoxicity in the developing brain, so named anesthesia-induced developmental neurotoxicity. Even though many experimental studies using animal models indicated some adverse effect of anesthetics, more evidence is needed before a recommendation can be made to change the way those anesthetics are used in the pediatric population. Two large clinical trials are underway and may provide insight to the potential human neurotoxic effect of anesthetics.
摘要
我们进行了PubMed检索，并总结了关于麻醉剂潜在不良影响的研究，尤其是其对发育中大脑的神经毒性，即所谓的麻醉诱导发育神经毒性。尽管许多使用动物模型的实验研究表明麻醉剂存在一些不良影响，但在能够建议改变儿科人群中麻醉剂的使用方式之前，还需要更多证据。两项大型临床试验正在进行中，可能会为麻醉剂对人类潜在的神经毒性影响提供见解。
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