Laboratory of Cell and Molecular Biology and Department of Zoology, University of Wisconsin-Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA; Oregon Institute of Marine Biology, University of Oregon, P.O. Box 5389, Charleston, OR 97420, USA.
Laboratory of Cell and Molecular Biology and Department of Zoology, University of Wisconsin-Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA.
Curr Opin Cell Biol. 2014 Feb;26:51-9. doi: 10.1016/j.ceb.2013.09.005. Epub 2013 Oct 23.
A major goal of developmental biology is to explain the emergence of pattern in cell layers, tissues and organs. Developmental biologists now accept that reaction diffusion-based mechanisms are broadly employed in developing organisms to direct pattern formation. Here we briefly consider these mechanisms and then apply some of the concepts derived from them to several processes that occur in single cells: wound repair, yeast budding, and cytokinesis. Two conclusions emerge from this analysis: first, there is considerable overlap at the level of general mechanisms between developmental and single cell pattern formation; second, dynamic structures based on the actin cytoskeleton may be far more ordered than is generally recognized.
发育生物学的一个主要目标是解释细胞层、组织和器官中模式的出现。发育生物学家现在接受了基于反应扩散的机制在指导模式形成中被广泛应用于发育生物体的观点。在这里，我们简要地考虑这些机制，然后将从中得出的一些概念应用于发生在单细胞中的几个过程：伤口修复、酵母出芽和胞质分裂。从这个分析中得出两个结论：第一，在发育和单细胞模式形成的一般机制层面上有相当大的重叠；第二，基于肌动蛋白细胞骨架的动态结构可能比通常所认识的要有序得多。
