Department of Psychology, University of Oslo, P.O. Box 1094, Blindern, NO-0317 Oslo, Norway.
Vestre Viken Hospital Trust, Norway.
Psychiatry Res. 2014 Apr 30;216(1):1-5. doi: 10.1016/j.psychres.2014.01.031. Epub 2014 Jan 30.
In a Norwegian ongoing longitudinal study, we investigate the neurocognitive development in first-episode schizophrenia patients, and the influence of neurocognition on remission and real life functioning. In the present study, results from the early course of illness are reported. The sample includes 28 schizophrenia spectrum patients and 28 pairwise matched healthy controls. The patients were recruited from mental health service institutions and data on psychosocial functioning, remission and neurocognition were obtained through a clinical interview, an inventory on social and role functioning, operational criteria of remission, and a standardized neurocognitive test battery, the MATRICS Consensus Cognitive Battery (MCCB). Large effect size differences between patients and controls were observed at baseline on every cognitive domain, as well as statistically significant improvements on overall cognitive function at follow-up for the patient group. A remission rate of 61% was found. The neurocognitive baseline measure of Attention significantly predicted remission status at follow-up, whereas Attention and Working Memory at baseline predicted levels of social and role functioning. In the early course of the illness, more than half of the group of first-episode patients were in remission, and neurocognitive functions are significantly associated with both remission of symptoms and social and role functioning.
在挪威一项正在进行的纵向研究中，我们调查了首发精神分裂症患者的神经认知发展，以及神经认知对缓解和现实生活功能的影响。本研究报告了疾病早期的结果。样本包括 28 名精神分裂症谱系患者和 28 名配对的健康对照。患者从精神卫生服务机构招募，通过临床访谈、社会和角色功能清单、缓解的操作性标准以及标准化神经认知测试组合，即 MATRICS 共识认知电池 (MCCB)，获得心理社会功能、缓解和神经认知的数据。在基线时，患者组的每个认知领域都观察到与对照组相比存在较大的效应量差异，以及在随访时整体认知功能的统计学显著改善。发现缓解率为 61%。注意力的神经认知基线测量值显著预测随访时的缓解状态，而注意力和工作记忆在基线时预测社会和角色功能的水平。在疾病的早期，首发精神分裂症患者中有一半以上处于缓解状态，神经认知功能与症状缓解和社会及角色功能显著相关。
