Department of Psychology, University of Oslo, Norway.
Vestre Viken Hospital Trust, 3004 Drammen, Norway.
Psychiatry Res. 2015 Jun 30;227(2-3):185-91. doi: 10.1016/j.psychres.2015.03.037. Epub 2015 Apr 8.
Lack of control of confounding variables, high attrition rate, and too few neurocognitive domains completed at each assessment point are some of the limitations identified in studies of the relationship between cognition and functional outcome in schizophrenia. In the ongoing Oslo multi-follow-up study 28 first episode schizophrenia patients and a pairwise matched control group (N=28) are assessed with the MATRICS Consensus Cognitive Battery (MCCB), a clinical interview, an inventory on social and role functioning and criteria of remission and recovery at several follow-up points. The current paper describes the rate of remission and full recovery, and investigates the relationship between neurocognition and functional outcome. At 2-year follow-up, 80.0% of the patients were in remission and 16.0% of them fulfilled the criteria for full recovery. The attrition rate was very low. In the follow-up period, there was a statistically significant decline in Verbal Learning and a significant improvement on Reasoning/Problem Solving and Social Cognition in the schizophrenia group, but not in the control group. This indicates a differentiated neurocognitive course. In the schizophrenia group, Attention/Vigilance and years of education at baseline were significant predictors of social and role functioning 2 years later.
在研究精神分裂症认知功能与功能结局的关系时，一些研究存在混杂变量控制不足、失访率高以及每个评估点完成的神经认知域太少等局限性。在正在进行的奥斯陆多随访研究中，28 名首发精神分裂症患者和 28 名配对对照组患者接受了 MATRICS 共识认知成套测验（MCCB）、临床访谈、社会和角色功能清单以及在几个随访点的缓解和恢复标准的评估。本论文描述了缓解率和完全恢复率，并探讨了神经认知与功能结局的关系。在 2 年随访时，80.0%的患者达到缓解，16.0%的患者达到完全缓解标准。失访率非常低。在随访期间，精神分裂症组的言语学习呈显著下降趋势，推理/问题解决和社会认知呈显著改善趋势，但对照组没有这种变化。这表明存在神经认知的分化过程。在精神分裂症组中，基线时的注意力/警觉性和受教育年限是 2 年后社会和角色功能的显著预测因素。
