IRCCS Centro S. Giovanni di Dio, Fatebenefratelli, Brescia, Italy.
Institute of Psychiatry, University of Catania, Catania, Italy.
Neurosci Lett. 2014 Apr 30;566:320-5. doi: 10.1016/j.neulet.2014.02.001. Epub 2014 Feb 11.
A large number of studies investigated the genetic modulation of personality with mixed results. As a confirmatory analysis of previous findings, we firstly examined the association between several previously examined single nucleotide polymorphisms (SNPs) and personality traits in a sample of 158 healthy subjects. As a secondary aim, we tested the potential modulation of additional never previously investigated genes on personality. A blood sample was collected and the Temperament and Character Inventory (TCI) has been administered to all participants. Multivariate analysis of covariance, controlling for sex and age, was used to test SNP influence on TCI scores. Examination of previously studied gene variants showed an effect of adrenergic alpha 2B receptor (ADRA2B) on Cooperativeness and of serotonin receptor HTR2A on Self Directedness. Examination of new variants revealed that sex hormone binding protein (SHBG) was associated with reward dependence. Moreover, several additional variants showed a tendency towards association with some TCI traits, confirming previous results. This study suggests that ADRA2B, HTR2A and SHBG genes may be involved in the modulation of personality in healthy subjects. The major limitation of this study was the small sample size.
大量研究调查了人格的遗传调节作用，结果喜忧参半。作为对先前发现的验证性分析，我们首先在 158 名健康受试者的样本中检验了几个先前研究过的单核苷酸多态性（SNP）与人格特质之间的关联。作为次要目标，我们测试了其他从未研究过的基因对人格的潜在调节作用。采集了血样并对所有参与者进行了气质与性格问卷（TCI）测试。使用多元协方差分析，控制性别和年龄，检验 SNP 对 TCI 评分的影响。对先前研究过的基因变异的检查显示，肾上腺素能α 2B 受体（ADRA2B）对合作性有影响，5-羟色胺受体 HTR2A 对自我导向性有影响。对新变异的检查表明，性激素结合蛋白（SHBG）与奖赏依赖有关。此外，还有几个额外的变异与 TCI 特征有一定的关联趋势，证实了先前的结果。这项研究表明，ADRA2B、HTR2A 和 SHBG 基因可能参与了健康受试者人格的调节。本研究的主要局限性是样本量小。
