Italian National Institute for Health, Rome, Italy.
Italian National Institute for Health, Rome, Italy.
Regul Toxicol Pharmacol. 2014 Apr;68(3):447-67. doi: 10.1016/j.yrtph.2014.02.003. Epub 2014 Feb 12.
The persistence of metals in the environment and their natural occurrence in rocks, soil and water cause them to be present in the manufacture of pigments and other raw materials used in the cosmetic industry. Thus, people can be exposed to metals as trace contaminants in cosmetic products they daily use. Cosmetics may have multiple forms, uses and exposure scenarios, and metals contained in them can cause skin local problems but also systemic effects after their absorption via the skin or ingestion. Even this, cosmetics companies are not obliged to report on this kind of impurities and so consumers have no way of knowing about their own risk. This paper reviewed both the concentration of metals in different types of cosmetics manufactured and sold worldwide and the data on metals' dermal penetration and systemic toxicology. The eight metals of concern for this review were antimony (Sb), arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), mercury (Hg), nickel (Ni) and lead (Pb). This was because they are banned as intentional ingredients in cosmetics, have draft limits as potential impurities in cosmetics and are known as toxic.
金属在环境中的持久性及其在岩石、土壤和水中的自然存在,使得它们存在于制造色素和其他用于化妆品行业的原材料中。因此,人们在日常使用的化妆品中可能会接触到痕量污染物金属。化妆品可能有多种形式、用途和暴露情况,其中所含的金属在通过皮肤吸收或摄入后,不仅会导致皮肤局部问题,还会产生全身影响。即便如此,化妆品公司也没有义务报告这种杂质,因此消费者无从知晓自身面临的风险。本文综述了全世界制造和销售的不同类型化妆品中的金属浓度,以及关于金属经皮渗透和全身毒理学的数据。本次综述关注的八种金属为锑(Sb)、砷(As)、镉(Cd)、铬(Cr)、钴(Co)、汞(Hg)、镍(Ni)和铅(Pb)。这是因为它们被禁止作为化妆品的有意成分,作为化妆品中潜在杂质的草案限量,并且被认为是有毒的。