Serrani R E, Corchs J L
Cátedra de Fisiología, Fac. Cs. Médicas, Universidad Nacional de Rosario, Argentina.
Arch Int Physiol Biochim. 1987 Nov;95(4):341-6.
During the course of incubation, in vitro, in a saline medium, we found an increase of cell volume and Na+ content in human neonatal erythrocytes (NNE), from the umbilical cord. The increased cell volume was dependent on the major anion in the medium in that replacement of Cl- by NO-3 abolished the cell volume increase. In erythrocytes from adults neither the cell volume nor the sodium content were altered under similar incubation conditions. Furosemide-sensitive Na+ and K+ fluxes were at variance from those reported from adult erythrocytes. The differences here presented between both cell types would be another instance of changes observed to occur in erythrocytes during the postnatal period.
在体外生理盐水培养基中孵育过程中，我们发现来自脐带的人类新生儿红细胞（NNE）的细胞体积和Na⁺含量增加。细胞体积的增加取决于培养基中的主要阴离子，因为用NO₃⁻替代Cl⁻可消除细胞体积的增加。在类似的孵育条件下，成人红细胞的细胞体积和钠含量均未改变。速尿敏感的Na⁺和K⁺通量与成人红细胞报道的不同。这里呈现的两种细胞类型之间的差异将是出生后红细胞中观察到的变化的另一个例子。
