Weiss D J, Evanson O A, Geor R J
Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, St. Paul 55108.
Vet Res Commun. 1994;18(5):373-81. doi: 10.1007/BF01839288.
The effects of various concentrations of furosemide and pentoxifylline on equine RBC in vitro were evaluated to facilitate better understanding of the potential effects of these drugs on blood flow properties. Furosemide induced increased mean cell volume (MCV), increased RBC potassium concentration, increased whole blood viscosity, and decreased the RBC filtrability. These data indicate that furosemide may block the RBC membrane transport pathways resulting in potassium and water retention. The increase in size and the resultant decrease in the surface-area-to-volume ratio may have caused the impaired RBC filtrability and increased blood viscosity. Pentoxifylline improved RBC filtrability without changing the RBC size or the potassium or chloride concentrations, suggesting that pentoxifylline may increase the deformability of the RBC membrane. The study indicated that pentoxifylline has potential therapeutic applications for improving microvascular blood flow but that furosemide may have adverse effects on blood flow.
评估了不同浓度的呋塞米和己酮可可碱对马红细胞的体外作用，以更好地了解这些药物对血流特性的潜在影响。呋塞米导致平均细胞体积（MCV）增加、红细胞钾浓度升高、全血粘度增加以及红细胞过滤性降低。这些数据表明，呋塞米可能会阻断红细胞膜转运途径，导致钾和水潴留。细胞大小的增加以及表面积与体积比的相应降低可能导致红细胞过滤性受损和血液粘度增加。己酮可可碱在不改变红细胞大小、钾或氯浓度的情况下改善了红细胞过滤性，这表明己酮可可碱可能会增加红细胞膜的可变形性。该研究表明，己酮可可碱在改善微血管血流方面具有潜在的治疗应用，但呋塞米可能对血流产生不利影响。
