Zhang Chongben, Klett Eric L, Coleman Rosalind A
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA.
Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Clin Lipidol. 2013 Dec;8(6):659-667. doi: 10.2217/clp.13.67.
The metabolic syndrome, a cluster of metabolic derangements that include obesity, glucose intolerance, dyslipidemia and hypertension, is a major risk factor for cardiovascular disease. Insulin resistance has been proposed to be the common feature that links obesity to the metabolic syndrome, but the mechanism remains obscure. Although the excess content of triacylglycerol in muscle and liver is highly associated with insulin resistance in these tissues, triacylglycerol itself is not causal but merely a marker. Thus, attention has turned to the accumulation of cellular lipids known to have signaling roles. This review will discuss recent progress in understanding how glycerolipids and related lipid intermediates may impair insulin signaling.
代谢综合征是一组代谢紊乱，包括肥胖、葡萄糖不耐受、血脂异常和高血压，是心血管疾病的主要危险因素。胰岛素抵抗被认为是将肥胖与代谢综合征联系起来的共同特征，但其机制仍不清楚。尽管肌肉和肝脏中三酰甘油含量过高与这些组织中的胰岛素抵抗高度相关，但三酰甘油本身并非病因，而仅仅是一个标志物。因此，人们的注意力已转向已知具有信号传导作用的细胞脂质积累。本综述将讨论在理解甘油脂质和相关脂质中间体如何损害胰岛素信号传导方面的最新进展。
