Upadhayay Namrata, Paudel Bishnu Hari, Singh Paras Nath, Bhattarai Bal Krishna, Agrawal Kopila
Department of Physiology, B.P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal.
Department of Physiology, J.N. Medical College, A.M.U., Residence A-14, Medical Colony, Aligarh, 202002 India.
Indian J Otolaryngol Head Neck Surg. 2014 Jan;66(Suppl 1):133-7. doi: 10.1007/s12070-011-0378-4. Epub 2011 Nov 30.
Studies with ovarian hormones on auditory brainstem response (ABR) have conflicting reports although women have ABR shorter than men. This study compared ABR between pre- and postovulatory phases of menstrual cycle in consenting 40 healthy female volunteers (age 19 ± 2.35 years). The study was conducted under standard laboratory conditions (room temperature 26 ± 2°C) using Neuropack (Nihon Kohden machine, NM-420S; H636, Japan) and earphone dynamic receiver ELEGA (Type DR-531; no.237, Japan) in sound proof room. Ears were stimulated simultaneously using standard protocol. ABR was recorded in pre- and postovulatory phases. Ovulation was estimated by measuring basal body temperature. The ABR wave latencies (WLs) I, II, III, IV, V and inter-peak latencies (IPLs) I-III, III-V, I-V were compared between the two phases of menstrual cycle using paired t test. The postovulatory phase had shorter WL V (5.71 ± 0.18 ms vs. 5.81 ± 0.19 ms, p < 0.01), IPL III-V (1.89 ± 0.16 ms vs. 1.94 ± 0.19 ms, p < 0.05), and I-V (3.88 ± 0.16 ms vs. 3.95 ± 0.18 ms, p < 0.05) than in preovulatory. Other WLs and IPLs showed decreasing trend in postovulatory phase. ABR is better in postovulatory phase as compared to preovulatory phase probably due to progesterone hormone which might be involved in modulating auditory hearing pathway at postovulatory phase.
关于卵巢激素对听性脑干反应（ABR）的研究报告相互矛盾，尽管女性的ABR比男性短。本研究比较了40名自愿参与的健康女性志愿者（年龄19±2.35岁）月经周期排卵前和排卵后的ABR。该研究在标准实验室条件下（室温26±2°C）进行，使用日本光电仪器公司的Neuropack（NM - 420S型；H636，日本）和耳机动态接收器ELEGA（DR - 531型；编号237，日本），在隔音室内进行。使用标准方案同时刺激双耳。记录排卵前和排卵后的ABR。通过测量基础体温来估计排卵情况。使用配对t检验比较月经周期两个阶段的ABR波潜伏期（WLs）I、II、III、IV、V以及峰间潜伏期（IPLs）I - III、III - V、I - V。排卵后阶段的WL V（5.71±0.18毫秒对5.81±0.19毫秒，p < 0.01）、IPL III - V（1.89±0.16毫秒对1.94±0.19毫秒，p < 0.05）和I - V（3.88±0.16毫秒对3.95±0.18毫秒，p < 0.05）比排卵前阶段短。其他WLs和IPLs在排卵后阶段呈下降趋势。与排卵前阶段相比，排卵后阶段的ABR更好，这可能是由于孕激素在排卵后阶段可能参与调节听觉传导通路。
