自供电治疗性释放来自于在镁上的导电聚合物/氧化石墨烯薄膜。
Self-powered therapeutic release from conducting polymer/graphene oxide films on magnesium.
机构信息
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Nanomedicine. 2018 Oct;14(7):2495-2503. doi: 10.1016/j.nano.2017.02.021. Epub 2017 May 29.
Magnesium's complete in vivo degradation is appealing for medical implant applications. Rapid corrosion and hydrogen bubble generation along with inflammatory host tissue response have limited its clinical use. Here we electropolymerized a poly (3,4-ethylenedioxythiophene) (PEDOT) and graphene oxide (GO) film directly on Mg surface. GO acted as nano-drug carrier to carry anti-inflammatory drug dexamethasone (Dex). PEDOT/GO/Dex coatings improved Mg corrosion resistance and decreased the rate of hydrogen production. Dex could be released driven by the electrical current generated from Mg corrosion. The anti-inflammatory activity of the released Dex was confirmed in microglia cultures. This PEDOT/GO/Dex film displayed the ability to both control Mg corrosion and act as an on demand release coating that delivers Dex at the corrosion site to minimize detrimental effects of corrosion byproducts. Such multi-functional smart coating will improve the clinical use of Mg implants. Furthermore, the PEDOT/GO/Drug/Mg system may be developed into self-powered implantable drug delivery devices.
镁的完全体内降解对于医学植入物应用很有吸引力。但由于其快速腐蚀和氢气泡的产生以及炎症性宿主组织反应，限制了其在临床上的应用。在这里，我们在镁表面直接电聚合了聚（3,4-亚乙基二氧噻吩）（PEDOT）和氧化石墨烯（GO）薄膜。GO 作为纳米药物载体携带抗炎药物地塞米松（Dex）。PEDOT/GO/Dex 涂层提高了镁的耐腐蚀性并降低了氢气的生成速率。Dex 可以在由镁腐蚀产生的电流驱动下释放。在小胶质细胞培养物中证实了释放的 Dex 的抗炎活性。这种 PEDOT/GO/Dex 薄膜具有控制镁腐蚀和按需释放涂层的能力，可将 Dex 递送到腐蚀部位，以最大限度地减少腐蚀副产物的有害影响。这种多功能智能涂层将提高镁植入物的临床应用。此外，PEDOT/GO/药物/镁系统可能被开发成自供电可植入药物输送装置。
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