Wen Keren, Zhao Youjin, Zhang Feifei, Lui Su, Kemp Graham J, Gong Qiyong
Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan 610041, China.
iScience. 2022 Sep 8;25(10):105094. doi: 10.1016/j.isci.2022.105094. eCollection 2022 Oct 21.
Dysfunction of large-scale brain networks has been implicated in social anxiety disorder (SAD); most work has focused on grey matter (GM) functional connectivity (FC) abnormalities, whereas white matter (WM) FC alterations remain unclear. Here, using a K-means clustering algorithm, we obtained 8 GM and 10 WM functional networks from a cohort dataset (48 SAD patients and 48 healthy controls). By calculating and comparing FC matrices between SAD group and healthy controls, we demonstrated disrupted connections between the limbic and dorsal prefrontal, lateral temporal, and sensorimotor networks, and between the visual and sensorimotor networks. Furthermore, there were negative correlations between HAMD scores and limbic-dorsal prefrontal and limbic-sensorimotor networks, and between illness duration and sensorimotor-visual networks. These findings reflect the critical role of limbic network, with its extensive connections to other networks, and the neurobiology of disordered cognition processing and emotional regulation in SAD.
大规模脑网络功能障碍与社交焦虑障碍（SAD）有关；大多数研究集中在灰质（GM）功能连接（FC）异常，而白质（WM）FC改变仍不清楚。在此，我们使用K均值聚类算法，从一个队列数据集（48例SAD患者和48例健康对照）中获得了8个GM和10个WM功能网络。通过计算和比较SAD组与健康对照之间的FC矩阵，我们证明了边缘系统与背侧前额叶、颞叶外侧和感觉运动网络之间以及视觉与感觉运动网络之间的连接中断。此外，汉密尔顿抑郁量表（HAMD）评分与边缘系统-背侧前额叶和边缘系统-感觉运动网络之间以及病程与感觉运动-视觉网络之间存在负相关。这些发现反映了边缘系统网络的关键作用，其与其他网络有广泛连接，以及SAD中认知加工紊乱和情绪调节的神经生物学机制。
