B细胞刺激因子2（白细胞介素-6）对巨噬细胞抗菌活性的刺激作用。
Stimulation of antibacterial macrophage activities by B-cell stimulatory factor 2 (interleukin-6).
作者信息
Flesch I E, Kaufmann S H
机构信息
Department of Medical Microbiology and Immunology, University of Ulm, Federal Republic of Germany.
出版信息
Infect Immun. 1990 Jan;58(1):269-71. doi: 10.1128/iai.58.1.269-271.1990.
Abstract
Mononuclear phagocytes provide the major habitat of intracellular bacteria, including Mycobacterium tuberculosis and Mycobacterium bovis. The capacity of B-cell stimulatory factor 2 (interleukin-6 [IL-6]) to activate tuberculostatic functions was investigated by using murine bone marrow-derived macrophages (BMM phi). BMM phi stimulated with recombinant IL-6 and subsequently infected with M. bovis organisms failed to inhibit mycobacterial growth. In contrast, marked tuberculostasis was induced by IL-6 in BMM phi that were already infected with M. bovis, indicating that IL-6 has a macrophage-activating function.
摘要
单核吞噬细胞是包括结核分枝杆菌和牛分枝杆菌在内的细胞内细菌的主要生存场所。通过使用小鼠骨髓来源的巨噬细胞（BMM phi），研究了B细胞刺激因子2（白细胞介素-6 [IL-6]）激活抑菌功能的能力。用重组IL-6刺激并随后感染牛分枝杆菌的BMM phi未能抑制分枝杆菌的生长。相反，IL-6在已经感染牛分枝杆菌的BMM phi中诱导了明显的抑菌作用，表明IL-6具有巨噬细胞激活功能。
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