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Legionella pneumophila replication in macrophages inhibited by selective immunomodulatory effects on cytokine formation by epigallocatechin gallate, a major form of tea catechins.军团菌在巨噬细胞中的复制受到表没食子儿茶素没食子酸酯（茶儿茶素的主要形式）对细胞因子形成的选择性免疫调节作用的抑制。
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本文引用的文献

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The role of cell-mediated immunity in bacterial infections.细胞介导的免疫在细菌感染中的作用。
Rev Infect Dis. 1981 Nov-Dec;3(6):1221-50. doi: 10.1093/clinids/3.6.1221.
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Production of hybridoma growth factor by human monocytes.人单核细胞产生杂交瘤生长因子。
Eur J Immunol. 1987 Oct;17(10):1411-6. doi: 10.1002/eji.1830171004.
3
B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells.B细胞刺激因子2（β2干扰素）作为成熟小鼠T细胞产生白细胞介素2的第二信号发挥作用。
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Evidence for effects of interleukin 4 (B cell stimulatory factor 1) on macrophages: enhancement of antigen presenting ability of bone marrow-derived macrophages.白细胞介素4（B细胞刺激因子1）对巨噬细胞作用的证据：增强骨髓来源巨噬细胞的抗原呈递能力。
J Immunol. 1987 Jun 15;138(12):4275-9.
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Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.鉴定人26-kD蛋白，即干扰素β2（IFN-β2），为白细胞介素1和肿瘤坏死因子诱导产生的一种B细胞杂交瘤/浆细胞瘤生长因子。
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Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas.白细胞介素-HP1，一种由T细胞衍生的杂交瘤生长因子，可支持小鼠浆细胞瘤的体外生长。
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Functional discrimination between interleukin 6 and interleukin 1.白细胞介素6与白细胞介素1之间的功能差异
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Stimulation of murine hemopoietic colony formation by human IL-6.人白细胞介素-6对小鼠造血集落形成的刺激作用。
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B细胞刺激因子2（白细胞介素-6）对巨噬细胞抗菌活性的刺激作用。

Stimulation of antibacterial macrophage activities by B-cell stimulatory factor 2 (interleukin-6).

作者信息

Flesch I E, Kaufmann S H

机构信息

Department of Medical Microbiology and Immunology, University of Ulm, Federal Republic of Germany.

出版信息

Infect Immun. 1990 Jan;58(1):269-71. doi: 10.1128/iai.58.1.269-271.1990.

DOI:10.1128/iai.58.1.269-271.1990
PMID:2104600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC258443/
Abstract

Mononuclear phagocytes provide the major habitat of intracellular bacteria, including Mycobacterium tuberculosis and Mycobacterium bovis. The capacity of B-cell stimulatory factor 2 (interleukin-6 [IL-6]) to activate tuberculostatic functions was investigated by using murine bone marrow-derived macrophages (BMM phi). BMM phi stimulated with recombinant IL-6 and subsequently infected with M. bovis organisms failed to inhibit mycobacterial growth. In contrast, marked tuberculostasis was induced by IL-6 in BMM phi that were already infected with M. bovis, indicating that IL-6 has a macrophage-activating function.

摘要

单核吞噬细胞是包括结核分枝杆菌和牛分枝杆菌在内的细胞内细菌的主要生存场所。通过使用小鼠骨髓来源的巨噬细胞（BMM phi），研究了B细胞刺激因子2（白细胞介素-6 [IL-6]）激活抑菌功能的能力。用重组IL-6刺激并随后感染牛分枝杆菌的BMM phi未能抑制分枝杆菌的生长。相反，IL-6在已经感染牛分枝杆菌的BMM phi中诱导了明显的抑菌作用，表明IL-6具有巨噬细胞激活功能。