aAllergy and Respiratory Diseases Clinic, DIMI - University of Genoa, IRCCS AOU San Martino-IST, Genova, Italy bDepartment of Pediatrics, Nippon Medical School, Tokyo, Japan *Federica Arcadipane and Fiorenza Marugo contributed equally to the writing of this article.
Curr Opin Allergy Clin Immunol. 2014 Apr;14(2):168-76. doi: 10.1097/ACI.0000000000000043.
Allergic rhinitis due its high prevalence and burden needs to be properly treated. The disease's clinical features impose well tolerated drugs usable for long-term treatment. Nowadays, second-generation antihistamines and inhaled steroids represent the milestone of rhinitis therapy. The aim of the present review is to provide an update on allergic rhinitis treatment. A particular attention has been deserved to clinical trials, published in the last year that assess the efficacy and safety of new formulation of available drugs or new molecules.
Available and new drugs under investigation seem able to control rhinitis symptoms without a significant patient's burden. The challenge for the next years will be to improve treatment adherence rather than to introduce new drugs.
Allergic Rhinitis and its Impact on Asthma guidelines have brought attention to allergic rhinitis and its impact on asthma, but have also proposed a new classification in terms of symptoms severity and persistence useful for tailoring treatment on patients' phenotypes. Their further dissemination is needed; furthermore, they represent a cornerstone for the scientific community through a continuous update on relevant issues such as rhinitis phenotypes, disease management on the basis of new treatments, clinical trials transferability in real life, and allergic rhinitis management in public health programs.
由于变应性鼻炎的高患病率和负担，需要对其进行适当治疗。该疾病的临床特征需要使用耐受良好且可长期治疗的药物。目前，第二代抗组胺药和吸入性皮质类固醇代表了鼻炎治疗的里程碑。本综述旨在提供变应性鼻炎治疗的最新进展。特别关注了去年发表的评估现有药物新制剂或新分子疗效和安全性的临床试验。
现有和新研究的药物似乎能够控制鼻炎症状，而不会给患者带来明显的负担。未来几年的挑战将是提高治疗的依从性，而不是引入新的药物。
变应性鼻炎及其对哮喘的影响指南引起了对变应性鼻炎及其对哮喘的关注，但也根据症状严重程度和持续性提出了一种新的分类，这对于根据患者表型来调整治疗具有重要意义。需要进一步推广这些指南；此外，通过对相关问题（如鼻炎表型、基于新治疗方法的疾病管理、临床试验在现实生活中的可转移性以及公共卫生计划中的变应性鼻炎管理）的持续更新，这些指南为科学界提供了一个重要的基石。
