Himly Martin, Mills-Goodlet Robert, Geppert Mark, Duschl Albert
Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.
Front Immunol. 2017 Apr 25;8:471. doi: 10.3389/fimmu.2017.00471. eCollection 2017.
The type 2 immune response is an adaptive immune program involved in defense against parasites, detoxification, and wound healing, but is predominantly known for its pathophysiological effects, manifesting as allergic disease. Engineered nanoparticles (NPs) are non-self entities that, to our knowledge, do not stimulate detrimental type 2 responses directly, but have the potential to modulate ongoing reactions in various ways, including the delivery of substances aiming at providing a therapeutic benefit. We review, here, the state of knowledge concerning the interaction of NPs with type 2 immune responses and highlight their potential as a multifunctional platform for therapeutic intervention.
2型免疫反应是一种适应性免疫程序，参与抵御寄生虫、解毒和伤口愈合，但主要因其病理生理效应而为人所知，表现为过敏性疾病。据我们所知，工程纳米颗粒（NPs）是非自身实体，不会直接刺激有害的2型反应，但有潜力以多种方式调节正在进行的反应，包括递送旨在提供治疗益处的物质。在此，我们综述了关于纳米颗粒与2型免疫反应相互作用的知识状态，并强调了它们作为治疗干预多功能平台的潜力。
