Christensen J, Rick G A
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.
J Auton Nerv Syst. 1987 Dec;21(2-3):223-31. doi: 10.1016/0165-1838(87)90025-7.
Slow waves in the small intestine seem to arise in plexuses of neurites with interstitial cells of Cajal. In the colon, slow waves appear to arise at the circular muscle - submucosal interface. We therefore sought a plexus at this surface in the colon in the cat, dog, ferret, opossum, rabbit, rat, guinea-pig and man. Segments from all levels of the colon were stained by the Champy-Maillet osmic acid-zinc iodide method and cut into serial 25 micron sections in the plane of the muscle layers. A dense network of neurites with abundant interstitial cells of Cajal was found at the circular muscle - submucosal interface in all species except rabbit. Neurites in this plexus appeared to arise from the deep plexus of the submucosa (Schabadasch's or Henle's plexus). It was not found in the small intestine and stomach. A similar plexus was found in the interstices of the myenteric plexus in the colon. Interstitial cells of Cajal in both plexuses were positive for the NADH-diaphorase stain, but not for silver impregnation. The possible roles of the plexuses of neurites and interstitial cells of Cajal at the circular muscle - submucosal interface and at the plane of the myenteric plexus in the generation of rhythmic activity in the colon are discussed.
小肠中的慢波似乎起源于神经突与 Cajal 间质细胞形成的神经丛。在结肠中，慢波似乎起源于环形肌 - 黏膜下层界面。因此，我们在猫、狗、雪貂、负鼠、兔子、大鼠、豚鼠和人类的结肠该表面寻找神经丛。用 Champy-Maillet 锇酸 - 碘化锌法对结肠各段进行染色，并在肌层平面切成 25 微米的连续切片。除兔子外，在所有物种的环形肌 - 黏膜下层界面均发现了一个由丰富的 Cajal 间质细胞组成的密集神经突网络。该神经丛中的神经突似乎起源于黏膜下层的深神经丛（Schabadasch 神经丛或 Henle 神经丛）。在小肠和胃中未发现该神经丛。在结肠的肌间神经丛间隙中也发现了类似的神经丛。两个神经丛中的 Cajal 间质细胞对 NADH - 黄递酶染色呈阳性，但对银浸染呈阴性。本文讨论了环形肌 - 黏膜下层界面以及肌间神经丛平面处的神经突和 Cajal 间质细胞神经丛在结肠节律性活动产生中的可能作用。
