眼内冲洗液中低分子右旋糖酐对视网膜电图B波的影响。

Effects of low molecular weight dextran in intraocular irrigating solutions on ERG B-wave.

作者信息

Kim S Y, Nao-i N, Honda Y

机构信息

Department of Ophthalmology, Kyoto University Faculty of Medicine, Japan.

出版信息

Metab Pediatr Syst Ophthalmol (1985). 1985;8(4):166-8.

PMID:2453779

Abstract

We examined effects of low molecular weight dextran in intraocular irrigating solutions on in vitro ERGs of the rabbit. A significant difference in ERG b-wave amplitude was observed between dextran-free and 3-4% dextran-added solutions. The b-wave amplitudes were well maintained and even enhanced to 120% of the presubstitution level after 90 minutes incubation with 4% dextran-added solution (15 mM/L bicarbonate, 290 M0sm/kg). It is suggested that low molecular weight dextran might be a useful or, at least, non-toxic agent in intraocular irrigating solutions for maintaining the retinal function with respect to ERG b-wave.

摘要

我们研究了眼内冲洗液中低分子量右旋糖酐对兔体外视网膜电图（ERG）的影响。在不含右旋糖酐的溶液和添加了3 - 4%右旋糖酐的溶液之间，观察到ERG b波振幅存在显著差异。在用添加了4%右旋糖酐的溶液（15 mM/L碳酸氢盐，290 mOsm/kg）孵育90分钟后，b波振幅得到良好维持，甚至增强至置换前水平的120%。这表明低分子量右旋糖酐在眼内冲洗液中可能是一种有用的，或者至少是无毒的药物，可用于维持视网膜功能的ERG b波。