用单克隆抗体筛选的新城疫病毒意大利株抗原变异体的致病性
Pathogenicity of antigenic variants of Newcastle disease virus Italian strain selected with monoclonal antibodies.
作者信息
Meulemans G, Gonze M, Carlier M C, Petit P, Burny A, Long L E
机构信息
National Institute for Veterinary Research, Brussels, Belgium.
出版信息
Ann Rech Vet. 1987;18(4):371-4.
Antigenic variants of the Italian strain of NDV were selected using monoclonal antibodies directed against the HN and F proteins of Italian virus. Antigenic mapping of the HN and F proteins using variant viruses in cross neutralization tests revealed the presence of at least two different epitopes on HN and four epitopes on F protein. Immunoselected variant viruses were demonstrated to have different intravenous pathogenicity index than the parental Italian virus.
利用针对意大利新城疫病毒（NDV）HN和F蛋白的单克隆抗体筛选出意大利毒株的抗原变异体。在交叉中和试验中，使用变异病毒对HN和F蛋白进行抗原定位，结果显示HN上至少存在两个不同的表位，F蛋白上存在四个表位。免疫筛选出的变异病毒经证实，其静脉内致病性指数与亲本意大利病毒不同。
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