新城疫病毒融合蛋白的F1和F2亚基上的突变赋予了对单克隆抗体中和作用的抗性。
Mutations located on both F1 and F2 subunits of the Newcastle disease virus fusion protein confer resistance to neutralization with monoclonal antibodies.
作者信息
Neyt C, Geliebter J, Slaoui M, Morales D, Meulemans G, Burny A
机构信息
Laboratory of Biological Chemistry, Free University of Brussels, Belgium.
出版信息
J Virol. 1989 Feb;63(2):952-4. doi: 10.1128/JVI.63.2.952-954.1989.
Abstract
The fusion gene sequence of six Newcastle disease virus escape mutants revealed that residues important for the integrity of antigenic site 1 and antigenic site 2 were located, respectively, on the F2 subunit and within the cysteine-rich domain of the F1 subunit. We further report the antibody-binding capacity of these mutants.
摘要
六种新城疫病毒逃逸突变体的融合基因序列显示，对抗原位点1和抗原位点2完整性至关重要的残基分别位于F2亚基上和F1亚基富含半胱氨酸的结构域内。我们进一步报告了这些突变体的抗体结合能力。
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