Zilov V G, Rogacheva S K, Ivanova L I, Misina E I
Biull Eksp Biol Med. 1988 May;105(5):563-5.
Substance P (SP) effects on the central mechanisms of escape reaction, elicited by threshold electrical stimulation of the ventromedial hypothalamus were investigated in rabbits pretreated with ethanol (0.5 g/kg). SP (30 micrograms/kg) was demonstrated to normalize in 71.4% of cases the excitability of the ventromedial hypothalamus which was decreased by ethanol and restored in 83.3% of cases the facilitatory effects of the midbrain reticular formation in escape reactions. However, SP was ineffective in the restoration of the inhibitory effects of the dorsal hippocamp on the excitability of the ventromedial hypothalamus that was obvious in intact animals. Partial normalizing effect of SP on escape reaction in rabbits after previous ethanol administration can be accounted for by the fact that both undecapeptide and ethanol are similar in their realization of central effects such as an interaction with the same brain neurotransmitters, interference with neuronal enzyme processes and reactions with opiate receptors.
在预先给予乙醇（0.5克/千克）的家兔中，研究了P物质（SP）对由腹内侧下丘脑阈下电刺激引发的逃避反应中枢机制的影响。结果表明，SP（30微克/千克）可使71.4%的因乙醇而兴奋性降低的腹内侧下丘脑恢复正常，并使83.3%的中脑网状结构在逃避反应中的易化作用恢复。然而，SP对完整动物中明显存在的背侧海马对腹内侧下丘脑兴奋性的抑制作用的恢复无效。SP对先前给予乙醇的家兔逃避反应的部分正常化作用，可归因于该十一肽和乙醇在实现中枢效应方面相似，例如与相同的脑内神经递质相互作用、干扰神经元酶过程以及与阿片受体反应。
