Zilov V G, Rogacheva S K, Ivanova L I
Fiziol Zh Im I M Sechenova. 1992 Dec;78(12):22-9.
Ability of the substance P to enhance the tolerance of feeding and defence motivations of ethanol was studied in rabbits. Ethanol led to disintegration of central mechanisms of both feeding and escape responses elicited by a threshold electrical stimulation of lateral and ventromedial hypothalamic centres. Subsequent i.v. administration of the substance P restored the effects of midbrain RF on the motivational centres. The inhibitory effect of the dorsal hippocampus and the facilitatory effect of the midbrain RF on excitability of the lateral hypothalamus, are also restored. The data obtained suggest that the substance P is able to increase a tolerance of the central mechanisms of biological motivations of ethanol.
在兔子身上研究了P物质增强对乙醇摄食和防御动机耐受性的能力。乙醇导致由下丘脑外侧和腹内侧中心阈值电刺激引发的摄食和逃避反应的中枢机制瓦解。随后静脉注射P物质恢复了中脑网状结构对动机中枢的作用。背侧海马体的抑制作用和中脑网状结构对下丘脑外侧兴奋性的促进作用也得以恢复。所获得的数据表明，P物质能够提高乙醇生物动机中枢机制的耐受性。
