Zilov V G, Rogacheva S K, Ivanova L I, Misina E I
Zh Vyssh Nerv Deiat Im I P Pavlova. 1989 Mar-Apr;39(2):343-8.
Ethanol (0.5 g/kg) administered intravenously led to alterations in central mechanisms of feeding and escape, elicited by threshold electrical stimulation either of lateral or of ventromedial hypothalamic centers of the rabbit. Subsequent intravenous injection of substance P (30 mcg/kg) restored the excitability of the ventromedial hypothalamus and facilitatory effects on this motivational center of the midbrain reticular formation. The restoration of both inhibitory influences of the dorsal hippocampus and facilitatory ones of the midbrain reticular formation on the excitability of the lateral hypothalamus was also observed after SP administration. Data obtained suggest that oligopeptides could be used to increase the tolerance to ethanol or to cure the negative acute effects of alcohol in motivated behaviours.
静脉注射乙醇（0.5克/千克）会导致家兔外侧或腹内侧下丘脑中心的阈下电刺激所引发的进食和逃避中枢机制发生改变。随后静脉注射P物质（30微克/千克）可恢复腹内侧下丘脑的兴奋性，并对中脑网状结构的这一动机中枢产生促进作用。注射P物质后还观察到，背侧海马体对外侧下丘脑兴奋性的抑制作用以及中脑网状结构对其的促进作用均得以恢复。所获数据表明，寡肽可用于提高对乙醇的耐受性或消除酒精在动机行为方面的负面急性影响。
