溶血磷脂酸和载脂蛋白 A1 可预测患世界贸易中心肺损伤的风险增加：一项巢式病例对照研究。

Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study.

机构信息

Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University , New York, NY , USA .

出版信息

Biomarkers. 2014 Mar;19(2):159-65. doi: 10.3109/1354750X.2014.891047. Epub 2014 Feb 19.

DOI:10.3109/1354750X.2014.891047

PMID:24548082

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4306444/

Abstract

RATIONALE

Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV₁ < LLN.

METHODS

Nested case-control study of WTC-exposed firefighters. Cases had FEV₁ < LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured.

RESULTS

LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV₁ < LLN in a multivariable model.

CONCLUSIONS

Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV₁ < LLN.

摘要

理由

在世贸中心（WTC）暴露后血清中测量的代谢综合征、炎症和血管损伤标志物可预测 FEV1 异常。我们假设升高的 LPA 水平可预测 FEV₁<LLN。

方法

对 WTC 暴露的消防员进行巢式病例对照研究。病例组的 FEV₁<LLN。对照组来源于基线队列。测量了人口统计学、肺功能、血清脂质、LPA 和 ApoA1。

结果

与对照组相比，病例组的 LPA 和 ApoA1 水平更高，且与病例状态相关。在多变量模型中，LPA 使 FEV₁<LLN 的几率增加了 13%，而 ApoA1 使 FEV₁<LLN 的几率增加了 29%。

结论

升高的 LPA 和 ApoA1 可显著预测 FEV₁<LLN 的风险增加。

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Comparison of WTC dust size on macrophage inflammatory cytokine release in vivo and in vitro.

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Metabolic syndrome biomarkers predict lung function impairment: a nested case-control study.

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溶血磷脂酸和载脂蛋白 A1 可预测患世界贸易中心肺损伤的风险增加：一项巢式病例对照研究。

Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study.

机构信息

Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University , New York, NY , USA .

出版信息

Biomarkers. 2014 Mar;19(2):159-65. doi: 10.3109/1354750X.2014.891047. Epub 2014 Feb 19.

DOI:10.3109/1354750X.2014.891047

PMID:24548082

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4306444/

Abstract

RATIONALE

METHODS

Nested case-control study of WTC-exposed firefighters. Cases had FEV₁ < LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured.

RESULTS

LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV₁ < LLN in a multivariable model.

CONCLUSIONS

Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV₁ < LLN.

摘要

理由

在世贸中心（WTC）暴露后血清中测量的代谢综合征、炎症和血管损伤标志物可预测 FEV1 异常。我们假设升高的 LPA 水平可预测 FEV₁<LLN。

方法

对 WTC 暴露的消防员进行巢式病例对照研究。病例组的 FEV₁<LLN。对照组来源于基线队列。测量了人口统计学、肺功能、血清脂质、LPA 和 ApoA1。

结果

结论

升高的 LPA 和 ApoA1 可显著预测 FEV₁<LLN 的风险增加。

溶血磷脂酸和载脂蛋白 A1 可预测患世界贸易中心肺损伤的风险增加：一项巢式病例对照研究。

Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study.

机构信息

出版信息

RATIONALE

METHODS

RESULTS

CONCLUSIONS

理由

方法

结果

结论

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溶血磷脂酸和载脂蛋白 A1 可预测患世界贸易中心肺损伤的风险增加：一项巢式病例对照研究。

Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study.

机构信息

出版信息

RATIONALE

METHODS

RESULTS

CONCLUSIONS

理由

方法

结果

结论