Knott P D, Chan B, Ward R H, Chard T, Grudzinskas J G, Petrou M, Modell B
Department of Obstetrics and Gynaecology, School of Medicine, University College, London, U.K.
Eur J Obstet Gynecol Reprod Biol. 1988 Apr;27(4):277-81. doi: 10.1016/0028-2243(88)90039-1.
Chorionic villus sampling (CVS) is rapidly becoming established as a routine procedure for first-trimester fetal diagnosis. The technique can result in fetomaternal haemorrhage and this might sensitize Rhesus-negative mothers and on occasion lead to spontaneous abortion. Serial sampling indicates that there is a rapid rise in alphafetoprotein (AFP) levels following CVS; however, this is not reflected by raised levels at 16-18 weeks and does not influence the subsequent pregnancy outcome. Unlike AFP, alterations in hCG levels are small and variable. Anti-D prophylaxis for non-sensitized Rhesus negative mothers should be given after CVS and the procedure may be contra-indicated in patients who are already sensitized.
绒毛取样（CVS）正迅速成为早孕期胎儿诊断的常规程序。该技术可能导致母胎出血，这可能使Rh阴性母亲致敏，有时还会导致自然流产。连续取样表明，绒毛取样后甲胎蛋白（AFP）水平迅速上升；然而，在16 - 18周时水平并未升高，也不影响随后的妊娠结局。与AFP不同，hCG水平的变化较小且不稳定。未致敏的Rh阴性母亲在绒毛取样后应给予抗D预防，对于已经致敏的患者，该程序可能是禁忌的。
