Barkai G, Reichman B, Ries L, Lusky A, Lipitz S, Goldman B
Institute of Human Genetics, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Prenat Diagn. 1994 Sep;14(9):793-8. doi: 10.1002/pd.1970140905.
Maternal serum alpha-fetoprotein (AFP) and beta-human chorionic gonadotropin (beta hCG) measurements taken prior to chorionic villus sampling (CVS) in 21 patients who subsequently miscarried were compared with measurements in a control group of 113 patients with uneventful pregnancies. Patients with AFP levels of 10 iu/ml or more prior to the CVS had a 4.3 times greater risk of miscarriage (95 per cent confidence interval 1.3-13.6). AFP levels obtained 1 week after the CVS in the 13 patients with late miscarriages were higher than in the control group (P = 0.06). Patients miscarrying had a greater rise in AFP (P = 0.06) and a greater fall in beta hCG levels (P = 0.04) following the CVS procedure, compared with the control subjects. Each 10-unit change in the difference between AFP or beta hCG levels prior to and 1 week following the CVS was associated with a significantly increased risk for late miscarriage. Elevated maternal serum AFP levels early in pregnancy and changes in AFP and beta hCG levels following CVS may predict an increased risk for subsequent miscarriage.
对21例随后发生流产的患者在绒毛取样（CVS）前测定的母血清甲胎蛋白（AFP）和β-人绒毛膜促性腺激素（β-hCG）水平，与113例妊娠过程顺利的对照组患者的测定结果进行了比较。CVS前AFP水平为10 iu/ml或更高的患者流产风险高4.3倍（95%可信区间1.3 - 13.6）。13例晚期流产患者在CVS后1周测得的AFP水平高于对照组（P = 0.06）。与对照组相比，流产患者在CVS操作后AFP升高幅度更大（P = 0.06），β-hCG水平下降幅度更大（P = 0.04）。CVS前和后1周AFP或β-hCG水平差异每变化10个单位，晚期流产风险就显著增加。妊娠早期母血清AFP水平升高以及CVS后AFP和β-hCG水平变化可能预示随后流产风险增加。
