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雄激素性脱发中升高的双氢睾酮水平被选择出来，以保护男性免受前列腺癌的侵害。

Increased DHT levels in androgenic alopecia have been selected for to protect men from prostate cancer.

作者信息

Bhargava Shiva

机构信息

Cornell University, Ithaca, NY, USA.

出版信息

Med Hypotheses. 2014 Apr;82(4):428-32. doi: 10.1016/j.mehy.2014.01.016. Epub 2014 Jan 26.

DOI:10.1016/j.mehy.2014.01.016
PMID:24548754
Abstract

Androgenic alopecia, a condition characterized by increased levels of DHT could have been selected for due to the benefits that prostaglandin D2 (PGD(2)) has on the prostate. A DHT metabolite can increase the transcription of prostaglandin D2 synthase through estrogen receptor beta. The increase of PGD(2) can decrease the risk of prostate cancer and proliferation of prostate cancer cells. Therefore, the mechanisms behind male pattern baldness may also curtail the advancement of prostate cancer.

摘要

雄激素性脱发是一种以双氢睾酮（DHT）水平升高为特征的病症，可能由于前列腺素D2（PGD2）对前列腺有益而被选择保留下来。一种DHT代谢产物可通过雌激素受体β增加前列腺素D2合酶的转录。PGD2的增加可降低前列腺癌风险及前列腺癌细胞的增殖。因此，男性型秃发背后的机制也可能会抑制前列腺癌的进展。

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