Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sci Rep. 2018 Jun 27;8(1):9748. doi: 10.1038/s41598-018-28142-1.
The cancer risk in patients with alopecia areata (AA) or alopecia totalis (AT)/alopecia universalis (AU) remains unknown. In this study, national statistical data were used to study the association between these forms of alopecia and the risk of cancer. We enrolled 668,604 patients who were treated for alopecia from 2007 to 2014, and age- and sex-matched control subjects. AA and AT/AU patients had slightly higher overall cancer risks (hazard ratio (HR), 1.043; 95% confidence interval (CI), 1.022-1.065 and HR, 1.07; 95% CI, 1.013-1.129, respectively) than controls, after adjusting for confounding factors. The risks of oral cavity, esophagus, liver, biliary tract, pancreas, larynx, lung, kidney, breast, cervix, ovary, uterus, testis, nerve, and skin cancers; and lymphoma, multiple myeloma, and leukemia, were not increased in alopecia patients. In AA or AT/AU patients, the only increased risk was that of thyroid cancer. In AA patients alone, the risks of bladder and prostate cancers were increased. Thus, the cancer risks varied by the alopecia subtype. Careful monitoring is needed to explore if the actual risks of thyroid, bladder, and prostate cancers are increased in alopecia patients.
斑秃（AA）或全秃（AT）/普秃（AU）患者的癌症风险尚不清楚。本研究利用国家统计数据，研究了这些脱发形式与癌症风险之间的关联。我们纳入了 668604 例 2007 年至 2014 年因脱发接受治疗的患者，并按年龄和性别匹配了对照组。调整混杂因素后，AA 和 AT/AU 患者的总体癌症风险略高（风险比（HR），1.043；95%置信区间（CI），1.022-1.065 和 HR，1.07；95%CI，1.013-1.129）。口腔、食管、肝脏、胆道、胰腺、喉、肺、肾、乳腺、宫颈、卵巢、子宫、睾丸、神经和皮肤癌；以及淋巴瘤、多发性骨髓瘤和白血病的风险在脱发患者中并未增加。在 AA 或 AT/AU 患者中，唯一增加的风险是甲状腺癌。仅在 AA 患者中，膀胱癌和前列腺癌的风险增加。因此，癌症风险因脱发亚型而异。需要仔细监测以探讨脱发患者的甲状腺癌、膀胱癌和前列腺癌的实际风险是否增加。
