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[意大利北部博洛尼亚金属电镀工人的死亡率研究]

[Mortality study in metal electroplating workers in Bologna (Northern Italy)].

作者信息

Gerosa Alberto, Scarnato Corrado, Giacomozzi Giuseppe, d'Errico Angelo

机构信息

Azienda USL di Bologna, Dipartimento di sanità pubblica, Area prevenzione e sicurezza ambienti di lavoro, Bologna.

出版信息

Epidemiol Prev. 2013 Nov-Dec;37(6):376-85.

Abstract

AIM

to investigate general and cause-specific mortality of workers exposed to metals and other chemicals in the electroplating industry in Bologna Province.

MATERIALS AND METHODS

factory records of workers employed in 90 electroplating companies present in 1995 were used to build a cohort of subjects potentially exposed to carcinogenic and other substances in this industry, defined as "revised cohort", which was followed-up for mortality from 1960, or since first employment in an electroplating company if later, to 2008. Mortality risk was also examined separately in a subset of the cohort, composed of workers with at least one year of employment in electroplating, denominated "final cohort". Death rates of residents in Emilia-Romagna Region (Northern Italy) were used as a reference.

RESULTS

follow-up completeness was 99%. During the observation period, 533 deaths out of 2,983 subjects were observed in the revised cohort and 317 out of 1,739 in the final cohort. Significantly increased Standardized Mortality Ratios were estimated for overall mortality and for mortality from AIDS in the revised cohort and for bladder and rectal cancer in both cohorts.

CONCLUSIONS

the present study is, to authors' knowledge, the largest mortality investigation conducted in Italy on electroplating workers, for both size and temporal extension. The presence of excess mortality from causes of death not consistently associated in the literature with exposure to agents in this industry suggests that further research is needed to confirm these associations.

摘要

目的

调查博洛尼亚省电镀行业中接触金属和其他化学物质的工人的总死亡率和特定病因死亡率。

材料与方法

利用1995年存在的90家电镀公司员工的工厂记录,建立一个可能接触该行业致癌物质和其他物质的队列,定义为“修订队列”,从1960年开始随访死亡率,或从首次受雇于电镀公司(若更晚)开始,直至2008年。还在该队列的一个子集中单独检查了死亡风险,该子集由至少有一年电镀工作经历的工人组成,称为“最终队列”。以意大利北部艾米利亚 - 罗马涅地区居民的死亡率作为参考。

结果

随访完整性为99%。在观察期内,修订队列中的2983名受试者中有533人死亡,最终队列中的1739名受试者中有317人死亡。修订队列中总体死亡率和艾滋病死亡率以及两个队列中的膀胱癌和直肠癌死亡率的标准化死亡比均显著升高。

结论

据作者所知,本研究是意大利针对电镀工人进行的规模最大、时间跨度最长的死亡率调查。文献中未始终与该行业接触物质相关的死因存在超额死亡率,这表明需要进一步研究以证实这些关联。

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