组织驻留自然杀伤细胞及其潜在多样性。
Tissue-resident natural killer cells and their potential diversity.
作者信息
Sojka Dorothy K, Tian Zhigang, Yokoyama Wayne M
机构信息
Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China; Hefei National Laboratory for Physical Sciences at Microscale, Hefei, Anhui, China.
出版信息
Semin Immunol. 2014 Apr;26(2):127-31. doi: 10.1016/j.smim.2014.01.010. Epub 2014 Feb 16.
Abstract
Conventional NK cells are well characterized in the mouse spleen and circulate in the blood. Less well described are NK cells found in organs such as the liver, thymus, and uterus. Recently we identified a tissue-resident NK (trNK) cell population in the liver, suggesting a potential diversity of trNK cells in other organs. In this review we compare and contrast the similarities and differences among the subpopulations of NK and innate lymphoid cells to the trNK cells in the liver.
摘要
传统自然杀伤（NK）细胞在小鼠脾脏中已得到充分表征，并在血液中循环。而在肝脏、胸腺和子宫等器官中发现的NK细胞则描述较少。最近，我们在肝脏中鉴定出了一群组织驻留性NK（trNK）细胞，这表明其他器官中可能也存在不同的trNK细胞。在这篇综述中，我们比较并对比了NK细胞和固有淋巴细胞亚群与肝脏中trNK细胞之间的异同。
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