树突状细胞（DC）介导的交叉呈递中的新谜团。
A new RIDDle in DC-mediated cross-presentation.
机构信息
Department of Medicine, the Department of Pathology & Cell Biology, and the Department of Physiology & Cellular Biophysics, Columbia University Medical Center, New York, New York, USA.
出版信息
Nat Immunol. 2014 Mar;15(3):213-5. doi: 10.1038/ni.2826.
Abstract
Hyperactivity of a branch of the unfolded protein response in CD8α dendritic cells degrades endoplasmic reticulum–associated mRNAs, which leads to a defect in the cross-presentation of dead cell–derived antigens.
摘要
未折叠蛋白反应分支在 CD8α 树突状细胞中的过度活跃会降解内质网相关的 mRNA，导致死亡细胞衍生抗原的交叉呈递缺陷。
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