Lehmann F, Jenisch T, Helbig H, Gamulescu M A
Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland,
Ophthalmologe. 2015 May;112(5):424-8. doi: 10.1007/s00347-013-3007-7.
There are some reports showing isolated cases of drusen regression after pars plana vitrectomy (ppV) with peeling of the internal limiting membrane (iLM). Drusen characteristics after iLM peeling was investigated in this study.
The data of 527 patients who had received iLM peeling between 2004 and 2012 were retrospectively collected and those patients with retinal drusen were selected for the study. Fundus photographs before and after vitrectomy due to a macular hole or epiretinal gliosis were compared and drusen arrangement in the peeling site was analyzed. The aim of the study was to show whether there was drusen regression 2-5 months after surgery.
Out of the 527 patients 11 showed central macular drusen, 4 with confluent large drusen (> 63 µm diameter) and 7 with small hard drusen (≤ 63 µm diameter). One patient showed drusen regression after iLM peeling without any changes in the other eye and all other patients showed no differences in the drusen findings (n = 6) or even some additional drusen (n = 4) without drusen alterations in the other eye.
The results of this study could not confirm some reports showing drusen regression after iLM peeling in the peeling site in general and there was only one single case of central drusen regression.
有一些报告显示，在进行玻璃体视网膜内界膜（iLM）剥除的玻璃体切除术（ppV）后，出现了孤立的玻璃膜疣消退病例。本研究调查了iLM剥除后的玻璃膜疣特征。
回顾性收集了2004年至2012年间接受iLM剥除的527例患者的数据，并选择患有视网膜玻璃膜疣的患者进行研究。比较了因黄斑裂孔或视网膜前膜行玻璃体切除术前、后的眼底照片，并分析了剥除部位的玻璃膜疣排列情况。本研究的目的是显示术后2至5个月是否存在玻璃膜疣消退。
在527例患者中，11例有中心性黄斑玻璃膜疣，4例有融合性大玻璃膜疣（直径>63μm），7例有小的硬性玻璃膜疣（直径≤63μm）。1例患者在iLM剥除后出现玻璃膜疣消退，另一只眼无任何变化，所有其他患者的玻璃膜疣表现无差异（n = 6），甚至有4例出现了一些额外的玻璃膜疣，而另一只眼的玻璃膜疣无改变。
本研究结果无法证实一些报告中关于iLM剥除后剥除部位玻璃膜疣普遍消退的说法，仅出现了1例中心性玻璃膜疣消退的单一病例。
