Chanturiia A N, Shaturskiĭ O Ia, Nikolaenko A N, Lishko V K
Ukr Biokhim Zh (1978). 1989 Mar-Apr;61(2):85-9.
The action of pronase and latrotoxin antibodies on alpha-latrotoxin channels in lipid bilayers has been investigated. Proteolysis of the protruding portions of the inserted channels changed slightly its conductivity and selectivity. Latrotoxin antibodies added to either side of the membrane decreased channel conductivity. The effect depends on the membrane potential. It is suggested that the channel conformation depends on the transmembrane potential and selective centre localized in the inner region of a bilayer is insensitive to proteolysis of protruding segments.
已对链霉蛋白酶和α- 拉毒素抗体对脂质双层中α- 拉毒素通道的作用进行了研究。插入通道突出部分的蛋白水解使其电导率和选择性略有变化。添加到膜两侧的α- 拉毒素抗体降低了通道电导率。这种效应取决于膜电位。有人提出，通道构象取决于跨膜电位，且位于双层内部区域的选择性中心对突出片段的蛋白水解不敏感。
