Department of Biochemistry, Michigan State University, E. Lansing, Michigan, USA.
Planta. 1966 Mar;68(1):83-7. doi: 10.1007/BF00385373.
Germination of White Paris lettuce seeds is inhibited by 2-thiouracil up to 24 hours. This inhibition is reversed by RNA precursors only. Seedling growth of lettuce is inhibited by 2-thiouracil and 5-fluorouracil; and white the effect of 2-thiouracil is counteracted by RNA precursors, inhibition due to 5-fluorouracil is not reversed significantly by any nucleic acid precursors. Possibly 2-thiouracil controls germination and seedling growth by interfering with RNA synthesis, while the effect of 5-fluorouracil is non-specific.In the presence of gibberellic acid, 5-fluorouracil and 2-thiouracil are relatively ineffective in causing inhibition of hypocotyl growth. Mechanism of gibberellic acid action remains obscure.
2-硫代尿嘧啶对巴黎白莴苣种子的发芽有抑制作用，其抑制作用可持续 24 小时。这种抑制作用只能被 RNA 前体逆转。2-硫代尿嘧啶和 5-氟尿嘧啶抑制莴苣幼苗生长；而 2-硫代尿嘧啶的作用可以被 RNA 前体逆转，但 5-氟尿嘧啶的抑制作用不能被任何核酸前体显著逆转。2-硫代尿嘧啶可能通过干扰 RNA 合成来控制种子的发芽和幼苗的生长，而 5-氟尿嘧啶的作用则是非特异性的。在赤霉素存在的情况下，5-氟尿嘧啶和 2-硫代尿嘧啶在抑制下胚轴生长方面的效果相对较差。赤霉素作用的机制仍然不清楚。
