Hasegawa K, Kayano T
First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University, Japan.
J Oral Pathol. 1988 Feb;17(2):49-54. doi: 10.1111/j.1600-0714.1988.tb01506.x.
Thirty-one cases of early invasive squamous cell carcinoma (SCC) of the lateral border of the tongue were analyzed histologically; 9 were also serially sectioned. Three-dimensional reconstruction graphics showed that most of the invasive islands were connected with the adjacent epithelium, in spite of the apparent separation of islands on one histological section. Deep elongation, branching-off of rete processes and the narrowing of each junction of branches were frequently observed. Early invasive patterns were characteristic and classified into the following 4 prototypes: droplet (17 cases); elongating (12 cases); invaginating (1 case); and reticular (1 case) invasion. Marked cellular atypia was not often seen either in the carcinoma or the adjacent epithelium. Some of these cases showed little cellular atypia. These results suggested that not only cellular atypia, but also such morphological architectures (structural atypia), as the elongation and branching-off of rete processes, the increased number of separated islands, epithelial invagination, and the shortening of the distances between the surface epithelium and the underlying muscle layer, must be taken into consideration as being histological features of carcinomatous changes.
对31例舌外侧缘早期浸润性鳞状细胞癌进行了组织学分析；其中9例还进行了连续切片。三维重建图像显示，尽管在一个组织切片上各浸润岛看似分离，但大多数浸润岛与相邻上皮相连。常可见到 rete 突的深部延伸、分支以及各分支连接处变窄。早期浸润模式具有特征性，可分为以下4种原型：水滴状（17例）；延伸状（12例）；内陷状（1例）；网状（1例）浸润。在癌组织或相邻上皮中均不常出现明显的细胞异型性。其中一些病例细胞异型性很小。这些结果表明，作为癌性变化的组织学特征，不仅要考虑细胞异型性，还要考虑 rete 突的延伸和分支、分离岛数量增加、上皮内陷以及表面上皮与下方肌层之间距离缩短等形态结构（结构异型性）。
